The St. Jude LIFE study has provided a platform for numerous ancillary and extramurally funded studies. The U01 infrastructure support has facilitated research initiatives addressing a broad spectrum of survivorship outcomes- and intervention-based research as well as an award of a five-year training grant (Krull T32CA225590-01) for post-doctoral Training in Pediatric Cancer Survivorship Outcomes and Interventions, which has a focus on utilization of the SJLIFE cohort.

Grants Utilizing the SJLIFE Cohort

   

Funded

Efficacy of a Tobacco Quit Line for Childhood Cancer Survivors (QUITLINE) Principal Investigator: Robert Klesges Funding Source: NIH - 1R01CA127964 Award: $3,801,192 Dates of Funding: 01/29/2008- 11/31/2011

Evaluation of Long-term Effects of Anthracycline Induced Cardiotoxicity Principal Investigator: Greg Armstrong Funding Source: ASCO Award: $199,998 Dates of Funding: 07/01/2008 - 6/30/2011

Motor Proficiency and Physical Activity in Adult Survivors of Childhood ALL (MTRPAL) Principal Investigator: Kiri Ness Dates of Funding: 04/01/09 - 02/28/13 Funding Source: NCI - 5R01CA132901 Award: $2,582,369

Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors (NEULS) Principal Investigator: Kevin Krull Dates of Funding: 02/05/2010-12/31/2016 Funding Source: NIH/NIMH (National Institute of Mental Health) 1R01MH085849 Award: $ $2,590,459

Long-Term Treatment Related CNS Injury in Survivors of Childhood ALL (CNSRI) Principal Investigator: Greg Armstrong Dates of Funding: 07/01/2010 - 06/30/2012 Funding Source: NCI - 1R21CA138988 Award: $484,702

Genome-wide study of late effects of therapy in childhood cancer survivors Principal Investigator: Carmen Wilson Dates of Funding: 04/01/2011 - 03/31/2012 Funding Source: Rally Foundation Award: $15,000

Grants Utilizing SJLIFE Cohort

Genome-Wide Study of Platinum-Based Chemotherapy Principal Investigator: Carmen Wilson Dates of Funding: 04/01/2012 - 03/31/2013 Funding Source: Rally Foundation Award: $20,000

Low-dose Tamoxifen For Radiation-Induced Breast Cancer Risk Reduction: A Phase IIB Randomized Placebo-Controlled Trial (LDTAM) Principal Investigator: Melissa Hudson Dates of Funding: 10/01/2011 – 09/30/2017 Funding Source: UAB- NCI - 7R01CA140254 Award: $319,672

Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Congestive Heart Failure (PREVENT-CHF): A Phase IIB Randomized Placebo-Controlled Trial (PREVENT) Principal Investigator: Melissa Hudson Dates of Funding: 10/01/2011- 09/30/2014 Funding Source: COH- LLS Award: $126,660

Longitudinal Cardiotoxicity in Adult Survivors of Childhood Cancer (CARTOXII) Principal Investigator: Greg Armstrong Dates of Funding: 12/01/2011 - 11/30/2016 Funding Source: NCI - 1R01CA157838 Award: $3,051,065

Melatonin Intervention for Neurocognitive Deficits in the St. Jude Lifetime Cohort (MIND) Principal Investigator: Tara Brinkman Dates of Evaluation: 07/01/2012 – 05/01/2017 Funding Source: NIH/NCI (Cancer Center Development Funds) P30CA021765 Award: $170,000

Brain Integrity in Survivors of Hodgkin Lymphoma Treated with Thoracic Radiation (BRIGHT) Principal Investigator: Kevin Krull Funding Source: NCI - 5R01CA174794 Award: $3,912,366 Dates of Funding: 04/01/2013-03/31/2018

A Longitudinal Assessment of Frailty in young adult survivors of childhood cancer (FRAILTY) Principal Investigator: Kiri Ness Funding Sources: NCI - 1R01CA174851 Award: $3,513,537 Dates of Funding: 05/07/2014 – 04/30/2019

Feasibility and Efficacy of Transcranial Direct Current Stimulation (tDCS) and Cognitive Training for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALLSTIM) Principal Investigator: Kevin Krull Dates of Funding: 07/01/2014-06/30/2015 Funding Source: NIH/NCI (Cancer Center Development Funds) P30CA021765 Award: $69,000

Impact of resistance training and protein supplementation on lean muscle mass among childhood cancer survivors (REPS) Principal Investigator: Kiri Ness Funding Sources: AICR Award: $224,560 Dates of Funding: 01/01/2015 – 03/30/2018

The St. Jude Lifetime Cohort (SJLIFE U01) Principal Investigator: Melissa Hudson/Les Robison Funding Sources: NCI - 1U01CA195547 Award: $8,680,536 Dates of Funding: 07/09/2015 – 6/30/2020

Estimating the Late Effects Disease Burden of Childhood Cancer Survivors Principal Investigator: Nickhill Bhakta Funding Sources: St. Baldrick’s Foundation Award: $162,881 Dates of Funding: 07/01/2015 – 06/30/2017

Nutritional Status in Adult Survivors of Childhood Cancer Principal Investigator: Fang Fang Zhang Funding Sources: NCI - 1R03CA199516 Award: $41,008 Dates of Funding: 07/15/2015 – 06/30/2017

Pharmacogenomic of childhood leukemia ALL (SJLPLC) Principal Investigator: Bill Evans Funding Sources: NCI - 5R01CA036401 Award: $3,651,227 Dates of Funding: 07/25/2015 – 6/30/2020

Accelerating clinical adoption of PROMIS for chronically ill children: The child centered outcomes in practice and research (PEPR) Principal Investigator: I-Chan Huang Funding Sources: NCI - 1U19AR069525 Award: $88,839 Dates of Funding: 09/30/2015 - 10/01/2019

Symptom progress and adverse health outcomes in adult childhood cancer survivors (SYMPTOMS) Principal Investigator: I-Chan Huang/Kevin Krull Funding Sources: NCI - 1R21CA202210 Award: $490,438 Dates of Funding: 12/01/2015 - 11/30/2017

Improving cancer screening guidelines for survivors of childhood cancer Principal Investigator: Jennifer Yeh Funding Sources: ACS Award: $22,374 Dates of Funding: 07/01/2016 - 6/30/2020

Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma (FACES) Principal Investigator: Tara Brinkman Funding Sources: St. Baldrick’s Foundation Award: $212,866 Dates of Funding: 07/01/2015 - 6/30/2018

Reducing Risk of Anthracycline-related Heart Failure after Childhood Cancer- ALTE1621 (C-PREVENT) Principal Investigator: Melissa Hudson Funding Source: NCI – R01CA196854 Award: $200,380 Dates of Funding: 07/01/2015 - 6/30/2020

Late effects prediction using clinical phenotypes and whole genome sequencing Principal Investigator: Yutaka Yasui/Jinghui Zhang Funding Agency: NCI - 1R01CA216354 Award: $3,457,455 Dates of Funding: 04/01/2017 – 03/30/2022

Sleep apnea in survivors of childhood cancer treated with thoracic radiation Principal Investigator: Kevin Krull/Belinda Mandrell Funding Agency: NCI - 1R01CA215405 Award: $3,757,455 Dates of Funding: 07/01/2017 – 06/30/2022

Training in Pediatric Cancer Care Survivorship Principal Investigator: Kevin Krull Funding Agency: NIH/NCI, 1T32CA225590-01 Award: $1,149,057 Dates of Funding: 04/01/2018 – 03/31/2023

Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma Principal Investigator: Tara Brinkman Funding Sources: St. Baldrick’s Foundation Award: $229,998 Dates of Funding: 07/01/2018 - 6/30/2020

Submitted

Improving Delivery of Genetic Services to High Risk Childhood Cancer Survivors Principal Investigator: Todd Gibson Funding Agency: Univ of Chicago (Tara Henderson)/NCI

Immune Dysregulation and Premature Aging in Childhood Cancer Survivors: A Twin Study Principal Investigator: Todd Gibson Funding Agency: USC (Wendy Cozen)/NCI

Transcranial Direct Current Stimulation in Adult Survivor of Childhood Leukemia Principal Investigator: Tara Brinkman, Kevin Krull Funding Agency: NIH/NCI

Associations between telomere length, mitochondrial variation, methylation, age and frail health in childhood cancer survivors Principal Investigator: Kiri Ness/Zhaoming Wang Funding Agency: 1R01CA216349

Patient-Reported Outcomes Version of the CTCAE for Childhood Cancer Survivors Principal Investigator: I-Chan Huang Funding Agency: NIH/NCI, 1R01CA218397-01

Integrative Analysis of Late-Occurring Recurrent Adverse Outcomes in Childhood Cancer Survivors Principal Investigator: Yutaka Yasui Funding Agency: UTHSC (Liang Zhu) NCI

Genetic testing to Guide Pediatric Cancer and Follow Up: Using Anthracycline-associated Principal Investigator: Melissa Hudson Funding Agency: Boston Children’s (Yeh)

Associations between telomere length, mitochondrial variation, methylation, age and frail health in childhood cancer survivors Principal Investigator: Kiri Ness Funding Agency: 1R01CA232612-01A1

eHealth Intervention for Insomnia on Late Effects of Childhood Cancer Principal Investigator: Tara Brinkman Funding Agency: NCI

Neurostimulation in adult survivors of childhood leukemia Principal Investigator: Tara Brinkman Funding Agency: NCI

Mechanical Stimulation to Prevent Bone Loss in Children with ALL Principal Investigator: Kiri Ness Funding Agency: NCI

Prevalence and Risk of Frailty in Survivors of Childhood Cancer Principal Investigator: Todd Gibson/Kiri Ness Funding Agency: NCI

The St. Jude Lifetime Cohort Administrative Supplement Principal Investigator: Melissa Hudson Funding Agency: NCI

Auto-Adjusting Positive Airway Pressure for Obstructive Apnea in Cancer Survivors Administrative Supplement Principal Investigator: Kevin Krull Funding Agency: NCI

A Longitudinal Assessment of frailty in young adult survivors of childhood cancer Administrative Supplement Principal Investigator: Kiri Ness Funding Agency: NCI

Learn More About the Study

  • Organizational Structure

    The steering committee and working groups for St. Jude LIFE promote ingenuity, foster collaboration, and provide oversight. Learn more about this structure and process.

  • Study Design

    The St. Jude LIFE study includes retrospective analysis, prospective annual clinical assessments, and questionnaires. Review the study design and research methods.

  • Study Timeline

    Activated in 2007, view key milestones in the St. Jude LIFE study over the past 10+ years, including recruitment and on-site follow-up.

  • Core Infrastructure Activities

    Multiple areas of support, from internal research groups to external resources and collaborators, make St. Jude LIFE possible. Find out more about this infrastructure.

  • Concept / Ancillary Studies

    Learn about concept and ancillary studies on the St. Jude LIFE Study.

  • Publications

    Over 100 peer-reviewed, scientific journal articles and publications have been published from the St. Jude LIFE study. Get a full list of these publications to date.

  • Newsletters

    View newsletters from the St. Jude LIFE study to keep up to date on the study's findings and progress.